Arachidonic Acid Metabolism and Tumor Promotion by S. M. Fischer, T. J. Slaga (auth.), Susan M. Fischer, Thomas

By S. M. Fischer, T. J. Slaga (auth.), Susan M. Fischer, Thomas J. Slaga (eds.)

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88:854-860, 1979. , and Troll, W. Stimulation of human polymorphonuclear leukocytes superoxide anion radical production by tumor promoters. :154, 1981. W. A. Inhibition of phorbol esterstimulated chemiluminescence in human polymorphonuclear leukocytes by retinoic acid and 5,6 epoxyretinoic acid. Cancer Res. :216-222, 1981. M. A. Tumor promoter-induced chemiluminescence in mouse epidermal cells is inhibited by several inhibitors of arachidonic acid metabolism. , and Van Dyke, K. The generation of chemiluminescence by phagocytic cells.

M. ]. ), ARACHIDONIC ACID METABOLISM AND TUMOR PROMOTION. Copyright © 1985. Martinus NijhoJJ Publishing, Boston. All rights reserved. 49 3. PROSTAGLAi,DINS, EPIDERI·IAL HYPERPLASIA AND SKHJ TU",OR PROt/,OTlON G. FURSTENBERGER AND F. I"lARKS I. lpounds derived from 20-carbon polyunsaturatea fatty acias sucr, as aracrliaonic acia. iulus and the prostaglandins are modifiers of tissue response to that stimulLOs. lits their activity to the site of production. lay play important regulatory roles in individual cell functions, cell interactions and tissue homeostasis.

To test this hypothesis, Furstenberger and Marks (21) performed a bi ndi ng experiment 1ooki ng for receptor competiti on. TPA, however, did not compete for the establi shed PGE1 receptors of the adipose cen s. There is now substantial evidence to demonstrate that TPA provokes prostaglandin (and other arachidonic acid metabolites) synthesis in mouse epidermal cells. In a study by Brune et al (22) comparing a series of tigliane-, ingenane- and daphnane-type diterpene derivatives, it was found that a good correlation existed between irritant and promoting acitivity in mouse skin and PGE2 release in macrophages.

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Arachidonic Acid Metabolism and Tumor Promotion by S. M. Fischer, T. J. Slaga (auth.), Susan M. Fischer, Thomas
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