Amenorrhea: A Case-Based, Clinical Guide by Cary Dicken, Marie Menke, Genevieve Neal-Perry (auth.),

By Cary Dicken, Marie Menke, Genevieve Neal-Perry (auth.), Nanette F. Santoro, Genevieve Neal-Perry (eds.)

Amenorrhea: A Case-Based scientific advisor is a accomplished evaluation of the present wisdom concerning common woman reproductive body structure. Replete with fascinating case vignettes and supplying diagnostic algorithms and healing suggestions for amenorrhea, Amenorrhea: A Case-Based medical advisor is split into 3 sections. the 1st part consists of 2 chapters that offer an intensive evaluate of simple technology and scientific wisdom concerning the organ structures answerable for general body structure of the menstrual cycle. the second one part contains dialogue approximately menstrual cycle disruption because it pertains to hypothalamic-pituitary disorder, surgical and typical menopause, genetic defects, untimely ovarian failure/insufficiency and the results of caloric extra and restrict. The 3rd part deals an replace at the physiological results of lengthy amenorrhea precipitated surgically or by means of hypothalamic disorder and in addition comprises an unique bankruptcy that focuses completely at the influence of race and ethnicity at the incidence and prognosis of amenorrhea. Amenorrhea: A Case-Based scientific consultant brings jointly chapters from popular specialists who supply state of the art, clinically worthwhile info in a case-based, reader-friendly model. This identify can be a great addition to the bookshelves of all clinicians who perform in women’s health and wellbeing settings.

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Mol Cell Endocrinol 163:53–60 70. Meduri G, Bachelot A, Cocca MP, Vasseur C, Rodien P, Kuttenn F, Touraine P, Misrahi M (2008) Molecular pathology of the FSH receptor: new insights into FSH physiology. Mol Cell Endocrinol 282:130–142 71. Parrott JA, Skinner MK (1998) Thecal cell-granulosa cell interactions involve a positive feedback loop among keratinocyte growth factor, hepatocyte growth factor, and Kit ligand during ovarian follicular development. Endocrinology 139:2240–2245 72. McConnell NA, Yunus RS, Gross SA, Bost KL, Clemens MG, Hughes FM Jr (2002) Water permeability of an ovarian antral follicle is predominantly transcellular and mediated by aquaporins.

The initial repair of the endometrial surface, an event critical for the regeneration, occurs before cessation of menses and prior to the rise in estradiol [1, 2]. A measurable increase in endometrial thickness does not commence until this process is complete. Estradiol, produced by the ovaries on approximately day 4 or 5 (D4 or 5) of the cycle, induces growth and proliferation of the endometrium. The epithelial and stromal cells undergo mitoses and multiply, thus causing the glands to increase in length, while the stromal cells grow and expand the extracellular matrix [3].

For example, it is possible that a chromosomal translocation could disrupt a gene at the breakpoint, which could cause IHH/KS in that patient. Then, this gene becomes a candidate gene to test in other patients with IHH/KS who do not have chromosome abnormalities. It is also very reasonable to karyotype patients with multiple anomalies and IHH/KS, as this could indicate an unbalanced chromosomal rearrangement with the loss of multiple genes. Prader-Willi syndrome, due to a 15q deletion by FISH, should be considered if associated anomalies are present.

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Amenorrhea: A Case-Based, Clinical Guide by Cary Dicken, Marie Menke, Genevieve Neal-Perry (auth.),
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