Advances in Nephrourology by A. Vercellone (auth.), Michele Pavone-Macaluso, Philip H.

By A. Vercellone (auth.), Michele Pavone-Macaluso, Philip H. Smith, Antonio Vercellone, Rosario Maiorca, Ugo Rotolo (eds.)

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The renal biopsy provides only a static picture of this balance at one particular moment and the indications given may reflect only a transient situation. Therefore much attention has been devoted to the development of clinically useful ways of detecting immune complexes in the circulation in order to obtain reliable pathogenetic,diagnostic or prognostic information. More than 30 methods have been described for the detection of circulating IC. The direct demonstration of serum IC is possible only in experimental disease, injecting labelled antigens, or when the antigen, 3uch as a virus, is visiblp.

Exp. Med. 144: 428, (1976). H. et alii: A WHO collaborative study for the evaluation of 18 methods for detecting immune complexes in serum. J. Clin. Lab. Immunol. 1: 1, (1978). L. : Detection of circulating antigen-antibody complexes by their inhibitory effect on the agglutination of IgG-coated particles by rheumatoid factor or C1q. Clin. expo Immunol. 25: 21, (1976). C. : Immune complexes in sera and synovial fluids of patients with rheumatoid arthritis. Radioimmunoassay with monoclonal rheumatoid factor.

__ _ ---C 3 --..... -:.......... / 40 \ \ . E 1<>800: \, o Fig. 1. ,. C 4 ....... - ......... 60~ 2 months prednl~n. 0 \ 20 ---. - 4 ........... ........ 3 ' .. - --C C ~_ ... ,n. , ,hMmodialysl. pha"1ide 2 mg/ kg h-:omodialysis Renal function and levels of serum immune complexes in three patients with rapidly progressive glomerulonephritis. In mesangiocapillary GN and, moreover, in extracapillary. proliferative GN with granular IF we found IC levels significantly higher than those detected in healthy people.

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Advances in Nephrourology by A. Vercellone (auth.), Michele Pavone-Macaluso, Philip H.
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