Acute Exposure Guideline Levels for Selected Airborne by National Research Council, Board on Environmental Studies

By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels

This booklet is the 6th quantity within the sequence Acute publicity instruction degrees for Selected Airborne Chemicals, and contains AEGLs for chemical compounds similar to ammonia, nickel carbonyl and phosphine, between others.

At the request of the dep. of safety, the nationwide learn Council has reviewed the suitable medical literature compiled via a professional panel and tested Acute publicity guide degrees (AEGLs) for 12 new chemical substances. AEGLs signify publicity degrees less than which opposed overall healthiness results usually are not more likely to take place and are priceless in responding to emergencies similar to unintended or intentional chemical releases in the neighborhood, the place of work, transportation, the army, and for the remediation of infected sites.

Three AEGLs are authorized for every chemical, representing publicity degrees that lead to: 1) outstanding yet reversible ache; 2) long-lasting future health results; and three) life-threatening health and wellbeing impacts.

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2. Susceptible Populations Two populations exist that may be susceptible to allylamine toxicity due to their increased levels of plasma SSAO activity. This enzyme metabolizes allylamine to acrolein, hydrogen peroxide, and ammonia, which was shown to be a key step in allylamine-induced cardiovascular damage in several animal studies. Elevated levels of SSAO were found in patients with insulin-dependent diabetes mellitus (Boomsma et al. 1995) and congestive heart failure (Boomsma et al. 1997). SSAO levels increased with the severity of the disease, and patients with both maladies had higher SSAO levels than those with either malady alone.

Carcinogenicity No studies on the carcinogenicity of allylamine in humans were located (nor of its proposed metabolite, acrolein). S. Environmental Protection Agency (EPA) nor the International Agency for Research on Cancer (IARC) has classified allylamine as to its carcinogenic potential. 7. Summary No human data were located involving acute lethal exposure to allylamine. 5-10 ppm for 5 min, whereas exposure to about 14 ppm was immediately intolerable (Hine et al. 1960). There were several case reports and accidents involving occupational exposure to allylamine, in which workers experienced chest pain and respiratory irritation, although neither exposure durations nor concentrations were available.

An intraspecies uncertainty factor of 3 was applied because allylamine acts as a contact irritant, and the severity of its effects is not expected to vary greatly among humans. 2 ppm, which was a no-effect level for workers exposed for up to 4 h (Shell Oil Co. 1992). 42 ppm for 10 min to 8 h is also consistent with two mouse respiratory irritation studies (Gagnaire et al. 09 ppm would not (Alarie 1981). AEGL-2 values were based on two studies. The 10-, 30-, and 60-min AEGLs were developed from the Hine et al.

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Acute Exposure Guideline Levels for Selected Airborne by National Research Council, Board on Environmental Studies
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